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Viagra is the first drug used for treating erectile dysfunction. Viagra is an oral therapy for erectile dysfunction, and is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP) a specific phosphodiesterase type 5 (PDE5).

Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7. Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

Did you Know?

Viagra Facts
  • Around 30 million men in the US alone suffer from clinical erectile dysfunction (ED)
  • More than 90% of the times there are identifiable biological problems
  • Viagra helps most men with erectile dysfunction achieve & maintain erection during sex
  • Viagra works in as little as 14 minutes
  • Viagra has a proven safety record

Viagra works for infact most of the men with erectile dysfunction. The main chemical ingredient for Viagra is sildenafil citrate which has the chemical powers to treat erectile dysfunction in men by increasing the blood flow to the penile tissues, and thus causing erection.

Viagra belongs to the class of PDE5 or phosphodiesterase inhibitor drugs. cGMP is a kind of chemical that helps in achieving erection and the moment the chemical PDE5 is released the erection goes flaccid. Hence the longer the onset of the chemical PDE5 can be delayed the longer would a man continue to enjoy erections. Hence Viagra works by inhibiting that chemical which causes the erections to go flaccid.

History of Viagra

Sildenafil, earlier known as compound UK-92,480, was initially developed to treat angina pectoris (a form of cardiovascular disease). In phase I during the clinical trials, the drug hardly showed any effects on angina; instead it had an interesting result. The compound showed marked improvements in the erectile problems of men. Thus the makers of Viagra decided to market the drug as an anti-impotence drug to treat erectile dysfunction rather than for angina.

The word Viagra was the invention of the manufacturers of this drug. It has close affinity in sound with the Sanskrit word vyaghra meaning tiger. Tiger itself is the symbol of strength, power and virility. Viagra also bears a close resemblance' in sound to the Niagra Falls which is a popular honeymoon destination for the couples and the word Niagra too evokes the feeling of vigor and virility and hence may be the name, Viagra.

Viagra was patented in 1996 for use in erectile dysfunction and was approved by the FDA on March 27, 1998, making the drug Viagra as the first oral pill to treat erectile dysfunction.


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